Basic Info.
Model NO.
AapCas12b, LbCas12a, LwaCas13a, LbuCas13a
CAS No.
Gsp9291, Gsp9292, Gsp9281, Gsp9282, Gsp9311, Gsp9312
Classification
Biochemical Reagents
Specific Usage
For Biological Purpose
Usage
Laboratory Reagents
Application
Scientific Research
Property
Enzyme & Coenzyme
Feature
High Purity, Simple, Efficient
Appearance
Colorless Liquid
Applications
Scientific Research, PCR
Transport Package
Carton Package
Specification
20µ L, 100µ L, 2mL
Product Description
Product Description
AapCas12bAlso known as C2cl, purified from E.coli strain containing the Alicyclobacillus acidophilus Cas12b expression gene. It belongs to
the V-type CRISPR Cas system. In the presence of PAM in the target DNA, it is a RNA mediated Nuclease that specifically targets to cut
double stranded DNA. The binding of LbCas12b crRNA complex with complementary single stranded DNA or double stranded DNA
releases strong non-specific ssDNA transcleavage activity. Compared to Casl3a, Cas12b can maintain higher activity under loop
mediated isothermal amplification (LAMP) reaction conditions.LbCas12aLbCas12a was purified from E.coli strain containing the Lachnospiraceae bacterium CRISPR-Cas12a expression gene. LbCas12a belongs to V-type CRISPR Cas system. In the presence of PAM in the target DNA, it is a RNA mediated Nuclease that specifically targets to cut double stranded DNA. Compared to Cas9, Cas12a only requires a single crRNA and has a smaller volume, making it easier to deliver into cells; At the same time, the combination of LbCas12a crRNA complex with complementary single stranded DNA or double stranded DNA releases strong non-specific ssDNA trans cleavage activity, which can be used for Genetic testing and imaging. LwaCas13aLwaCas13a was purified from E.coli strain containing the Leptotrichia wadei CRISPR-Cas13a (C2c2) expression gene. LwaCas13a is a type VI CRISPR Cas system, which is an RNA mediated Nuclease targeting RNA cleavage. LwaCas13a has high specificity and sensitivity, and can be used to detect individual RNA molecules. MIT Zhang Feng team has thus established the "SHERLOCK" molecular diagnosis system, which has broad application prospects in the field of Nucleic acid test.LbuCas13aLbuCas13a was purified from E.coli strain containing the expression gene of Leptotrichia buccalis CRISPR-Cas13a. LbuCas13a is a
type VI CRISPR Cas system, which is a RNA mediated Nuclease targeting RNA cleavage. LbuCas13a has high specificity and sensitivity, and can be used to detect individual RNA molecules. The Nobel Prize winner Doudna team has established a tandem CRISPR Nuclease system based on this, which has a broad application prospect in the field of Nucleic acid test.Applications: Multiple enzymes work together at room temperature to achieve rapid amplification of nucleic acids, which is a true POCT technology. It is a next-generation high sensitivity, high specificity, fast isothermal Nucleic acid test technology based on CRISPR detection development. |
Performance:
Address:
C1building, No. 11 Kaiyuan Road Science City, High-Tech Industrial Development District, Guangzhou, Guangdong, China
Business Type:
Manufacturer/Factory
Business Range:
Health & Medicine, Instruments & Meters
Company Introduction:
GuangDong Ardent Biomed Co., Ltd is an American medical technology company, initially founded as a product development and research lab in Silicon Valley California in 2011. In 2016 ABIOM established its Product manufacturing and Marketing Center and genetic testing service center in Guangzhou High-Tech Industrial Development Zone, With strong R&D team, ABIOM has developed over 120 products and owns 100 patents, including more than 20 authorized invention patents and two PCT invention patents.
With the mission of "Health Brings Prosperity", ABIOM focuses on Precision medicine and is committed to becoming an innovation leader on accurate diagnosis in immune and infectious diseases that accounts for 66% of the trillion IVD market.
Our vision is to "ABIOM improves health" Ardent has developed the world′s first leading Microfluidic HDL Subtyping System(with instrument and reagent kits), which improves the accurate detection and risk assessment of the world′s number one killer cardiovascular disease(CVD) at a very early period(before the age of 45).
ABIOM genetic testing service center covers its testing services with four categories: Immune and Inflammatory Diseases, Infectious Diseases, Reproductive Health, and Cancer.
Guangdong Ardent Biomed Co., Ltd is one of the very few high-tech IVD enterprises in China that provides a one-stop service from R&D to production of raw materials (enzyme etc. ), reagent kits, medical consumables, instruments, as well as molecular diagnostic services, expert interpretation and health management services.
The company founder, Dr. David Deng, has more than 20-year experience of leading diagnostic product R& AMP; D in Silicon Valleys of three world-known public companies: Agilent Tech, Varinata, Illumina and Ion Torrent, Thermofisher.
Our main business:
Whole range of Nucleic Acid Extraction kit, disposal sampling kit, Nucleic Acid Detection Kit etc.
Reagent kits, devices
Molecular diagnostic testing services
Research services